<p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt; LINE-HEIGHT: 150%; TEXT-INDENT: 31.5pt; mso-char-indent-count: 3.0"><font size="3"><span style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt">近日，77779193永利王艳丽教授课题组在国际顶尖期刊《</span><span lang="EN-US" style="FONT-FAMILY:  微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: "times new roman"">Advanced Materials</span><span style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt">》（先进材料，影响因子：</span><span lang="EN-US" style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: "times new roman"">21.95</span><span style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt">）上发表题为《</span><span lang="EN-US" style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: "times new roman"">A Highly Efficient Tumor-Targeting Nanoprobe with a Novel Cell Membrane Permeability Mechanism</span><span style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt">》的研究论文。并被编辑部邀请作为</span><span lang="EN-US" style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: "times new roman"">Video Abstracts</span><span style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: "times new roman"">（视频摘要）放在首页展览。</span><span style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt">《</span><span lang="EN-US" style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: "times new roman"">Advanced Materials</span><span style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt">》是材料与化学大领域的顶尖期刊。在国际材料领域科研界上享誉盛名！</span><span style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: "times new roman"">该论文是77779193永利， 上海海军军医大学，美国哈佛大学，新加坡国立大学共同合作完成的，77779193永利为第一通讯单位。</span></font></p>
<p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt; LINE-HEIGHT: 150%; TEXT-INDENT: 31.5pt; mso-char-indent-count: 3.0"><font size="3"><span style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: "times new roman""></span></font><font size="3"><span style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt">王艳丽教授课题组报道了"一种新型基于细胞膜通透性的高效肿瘤细胞核靶向荧光纳米探针"。长期以来，有效的肿瘤靶向一直是临床上的一大挑战。传统的基于实体瘤高通透性和滞留效应 </span><span lang="EN-US" style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: "times new roman"">(EPR)</span><span style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt">的靶向方法只有大约</span><span lang="EN-US" style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: "times new roman"">5%</span><span style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt">的靶向率。为了解决这一问题，一种基于石墨烯的肿瘤细胞核靶向荧光纳米探针<span lang="EN-US">(</span></span><span lang="EN-US" style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: "times new roman"">Graphene-based tumor cell nuclear targeting fluorescent nanoprobe , GTTN)</span><span style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt">被开发出来，具有全新的肿瘤靶向机制。</span><span lang="EN-US" style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: "times new roman"">GTTN</span><span style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt">是一种石墨烯<span lang="EN-US">-</span>单晶结构的两亲性荧光探针。该探针具有肿瘤细胞特异性靶向的特点，它通过肿瘤细胞膜高于正常细胞膜的通透性，直接穿过肿瘤细胞膜，并特异性靶向肿瘤细胞核。王艳丽教授将这种新的靶向机制命名为细胞膜通透性靶向</span><span lang="EN-US" style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: "times new roman"">(Cell membrane permeability targeting mechanism (CMPT)</span><span style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: "times new roman"">机</span><span style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt">制，这与</span><span lang="EN-US" style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: "times new roman"">EPR</span><span style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt">效应有很大的不同。这些探针可以在肿瘤早期识别肿瘤组织，并在单细胞水平上跟踪肿瘤细胞的侵袭转移情况。更重要的是，肿瘤靶向率从不足</span><span lang="EN-US" style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: "times new roman"">5%</span><span style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt">提高到</span><span lang="EN-US" style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: "times new roman"">50%</span><span style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt">以上。这一高效、精准的肿瘤细胞核靶向技术的实现将加速肿瘤诊疗新时代的到来。这一成果的后续研究及临床转化将会在77779193永利加大力度提升医学学科建设的进程中，不断推进，打造产学研医一体化发展的国际一流平台，实现基础研究的高效转化，贡献社会，造福人类。<span lang="EN-US"><o:p></o:p></span></span></font></p>
<p class="MsoNormal" style="TEXT-ALIGN: left; MARGIN: 0cm 0cm 0pt; LINE-HEIGHT: 150%; TEXT-INDENT: 36pt; mso-pagination: widow-orphan" align="left"><font size="3"><span style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt">王艳丽教授是77779193永利一手培养起来的优秀学生、青年教师，她带领团队，攻坚科学难题，也体现了上大人的精神和上大创新人才培养模式的成功。立足于本职工作，刻苦努力，踏实进取，校荣我荣，我为上大是努力奋斗、勇争一流的上大人的精神体现。 </span><span lang="EN-US" style="FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: 宋体; mso-font-kerning: 0pt"><o:p></o:p></span></font></p>
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<pre style="LINE-HEIGHT: 150%"><span style="FONT-SIZE: 10.5pt; FONT-FAMILY: " 微软雅黑","sans-serif"; line-height: 150%">论文链接： <span lang="EN-US"><a href="https://doi.org/10.1002/adma.201807456"><font color="#0563c1">https://doi.org/10.1002/adma.201807456</font></a></span></span></pre>
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